Congenital hypothyroidism with hereditary, raised thyroxine binding globulin.
نویسندگان
چکیده
منابع مشابه
Congenital hypothyroidism with hereditary, raised thyroxine binding globulin.
A boy with congenital hypothyroidism and hereditary raised thyroxine binding globulin is described. This hitherto unreported combination resulted in under treatment of the thyroid deficiency until serum thyroid stimulating hormone measurement became routinely available. Inadequate L-thyroxine replacement treatment between 2 and 7 years of age caused retarded bone maturation, poor growth velocit...
متن کاملNeonatal screening for congenital hypothyroidism based on thyroxine, thyrotropin, and thyroxine-binding globulin measurement: potentials and pitfalls.
CONTEXT The Dutch T(4)-TSH-TBG-based neonatal screening program detects patients with congenital hypothyroidism (CH) of thyroidal (CH-T) as well as central (CH-C) origin. The numbers and characteristics of true-positive and false-positive referrals will differ from other, predominantly TSH-based, screening methods. OBJECTIVE The present study describes the characteristics of the referred neon...
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Plasma thyroid hormone concentrations may be abnormal in non-thyroid disease and pose diagnostic problems. For example, concentrations of triiodothyronine (T3) in the blood decline in acute illness with a reciprocal increase in reverse triiodothyronine (reverse T3), but thyroxine (T4) concentrations are usually normal or only slightly decreased (1, 2). However, McLarty et al. (3) reported that ...
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Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemi...
متن کاملOptimisation of thyroxine dose in congenital hypothyroidism.
he introduction of the screening programme for congenital hypo-thyroidism in the late 1970s and early 1980s has been rightly hailed as a major success in the prevention of neurological handicap. With a prevalence of between 1/3000 and 1/5000 live births, congenital hypothyroidism is by far the commonest metabolic disorder leading to neurological handicap; given the inexpensive nature of assays ...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1985
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.60.8.766